Correlation between Variation of the 3′ Region of thecagAGene inHelicobacter pyloriand Disease Outcome in Japan | Zendy

Takeshi Azuma | Zendy; Akiyo Yamakawa | Zendy; Shiho Yamazaki | Zendy; Kanako Fukuta | Zendy; Masahiro Ohtani | Zendy; Yoshiyuki Ito | Zendy; Manabu Dojo | Zendy; Yukinao Yamazaki | Zendy; Masaru Kuriyama | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Correlation between Variation of the 3′ Region of thecagAGene inHelicobacter pyloriand Disease Outcome in Japan

Author(s) -

Takeshi Azuma,

Akiyo Yamakawa,

Shiho Yamazaki,

Kanako Fukuta,

Masahiro Ohtani,

Yoshiyuki Ito,

Manabu Dojo,

Yukinao Yamazaki,

Masaru Kuriyama

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/345374

Subject(s) - caga , helicobacter pylori , biology , pathogenicity island , genotype , gene , gastritis , atrophic gastritis , virulence , pathogenesis , genetics , microbiology and biotechnology , helicobacter , spirillaceae , immunology

Genetic diversity within the cag pathogenicity island (PAI) of Helicobacter pylori may have a modifying effect on the pathogenic potential of the infecting strain. The genetic structure of the cag PAI was examined in Japanese isolates. The composition and nucleotide sequences of the cag PAI were quite similar among strains; however, diversity between 2 cag genes (virB10 and cagA) was observed. The variety in the number of repetition of the 5-amino acid sequence R1 (EPIYA) in the 3' region of the cagA gene was identified. The frequencies of the genotypes that contained >4 R1 sequences were significantly higher in atrophic gastritis-causing strains than in duodenal ulcer-causing strains. One-third of strains with >4 R1 sequences were gastric cancer-causing strains. Although the cag PAI is conserved in H. pylori isolates in Japan, H. pylori infection with the cagA genotype with >4 R1 sequences may correlate with the pathogenesis of atrophic gastritis and gastric cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research