Minocycline‐Ethylenediaminetetraacetate Lock Solution for the Prevention of Implantable Port Infections in Children with Cancer | Zendy

Ioannis Chatzinikolaou | Zendy; Theodore F. Zipf | Zendy; Hend Hanna | Zendy; Jan Umphrey | Zendy; W. Mark Roberts | Zendy; Robert J. Sherertz | Zendy; Ray Hachem | Zendy; Issam Raad | Zendy

Open Access

Minocycline‐Ethylenediaminetetraacetate Lock Solution for the Prevention of Implantable Port Infections in Children with Cancer

Author(s) -

Ioannis Chatzinikolaou,

Theodore F. Zipf,

Hend Hanna,

Jan Umphrey,

W. Mark Roberts,

Robert J. Sherertz,

Ray Hachem,

Issam Raad

Publication year - 2003

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/344952

Subject(s) - medicine , minocycline , port (circuit theory) , adverse effect , prospective cohort study , cohort , lock (firearm) , surgery , cancer , heparin , antibiotics , microbiology and biotechnology , mechanical engineering , electrical engineering , biology , engineering

In this prospective cohort study, minocycline-ethylenediaminetetraacetate (M-EDTA) was used as a lock solution in indwelling ports inserted in 14 children with cancer. No port infections, thrombotic events, or other adverse events were observed, compared with 10 port infections that occurred in 48 control patients whose ports were flushed with heparin. M-EDTA is a promising lock solution in long-term catheters.

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