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To evaluate the efficacy of high-dose interferon (IFN) on human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection, 15 HIV-positive patients and 15 age-matched HIV-negative patients with hemophilia were treated with 9 million units (MU) of IFN-alpha2a daily for 2 weeks, followed by 9 MU of IFN-alpha2a 3 times/week for a further 22 weeks. At week 2, HIV RNA levels decreased from 7410+/-2190 to 320+/-130 copies/mL, and HCV RNA levels decreased from 390x10(3)+/-80x10(3) to 70x10(3)+/-30x10(3) copies/mL in the HIV-positive group and from 300x10(3)+/-80x10(3) to 10x10(3)+/-10x10(3) copies/mL in the HIV-negative group. HCV RNA was undetectable after treatment in 4 of 12 HIV-positive and 6 of 15 HIV-negative patients. IFN therapy was discontinued because of adverse effects in 3 HIV-positive patients. Induction therapy and the dose of IFN should be evaluated in combination therapy with IFN and ribavirin.

Efficacy of Induction Therapy with High‐Dose Interferon for Patients with Hemophilia and Human Immunodeficiency Virus–Hepatitis C Virus Coinfection