Chlamydial Heat‐Shock Protein–60 Antibody and Correlation withChlamydia pneumoniaein Atherosclerotic Plaques | Zendy

I. W. Fong | Zendy; Brian Chiu | Zendy; Esther Viira | Zendy; William Tucker | Zendy; Heidi Wood | Zendy; Rosanna W. Peeling | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chlamydial Heat‐Shock Protein–60 Antibody and Correlation withChlamydia pneumoniaein Atherosclerotic Plaques

Author(s) -

I. W. Fong,

Brian Chiu,

Esther Viira,

William Tucker,

Heidi Wood,

Rosanna W. Peeling

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/344730

Subject(s) - chlamydia , antigen , chlamydophila pneumoniae , chlamydiaceae , antibody , immune system , heat shock protein , chlamydiales , microbiology and biotechnology , immunology , biology , biochemistry , gene

A study was performed to determine whether serum antibody to Chlamydial heat-shock protein-60 (CHSP-60) and C-reactive protein (CRP) were associated with the presence of Chlamydia pneumoniae in atheromatous plaques in 75 patients. The mean (+/-SD) ELISA optical density (OD) of anti-CHSP-60 was 0.19+/-0.15 in 54 patients with detectable C. pneumoniae antigen, versus an OD of 0.11+/-0.08 in 21 patients without detectable C. pneumoniae I antigen (P=.008). Higher anti-CHSP-60 at an OD > or =0.12 was present in 38 (70.4%) of patients with detectable C. pneumoniae in atheromas, compared with 5 (23.8%) of patients without C. pneumoniae antigen (P<.001; 2-tailed test). The mean CRP concentration was 7.4+/-10.3 mg/L in patients with detectable C. pneumoniae antigen, versus 5.7+/-6.1 mg/L in those without (P=.556). Immune response to CHSP-60 may play a role in atherogenesis, but CRP serum levels does not appear to be related to C. pneumoniae infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research