A Genetic Analysis of Hepatitis C Virus Transmission between Injection Drug Users | Zendy

Alexandra Cochrane | Zendy; Benjamin Searle | Zendy; Alison Hardie | Zendy; Roy Robertson | Zendy; Toby Delahooke | Zendy; Sheila Cameron | Zendy; Richard S. Tedder | Zendy; Geoff Dusheiko | Zendy; Xavier de Lamballerie | Zendy; Peter Simmonds | Zendy

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A Genetic Analysis of Hepatitis C Virus Transmission between Injection Drug Users

Author(s) -

Alexandra Cochrane,

Benjamin Searle,

Alison Hardie,

Roy Robertson,

Toby Delahooke,

Sheila Cameron,

Richard S. Tedder,

Geoff Dusheiko,

Xavier de Lamballerie,

Peter Simmonds

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/344314

Subject(s) - ns5b , transmission (telecommunications) , virology , hepatitis c virus , genotype , phylogenetic tree , population , hepatitis c , biology , demography , injection drug use , virus , drug , medicine , drug injection , hepacivirus , genetics , gene , environmental health , pharmacology , human immunodeficiency virus (hiv) , sociology , electrical engineering , engineering

Hepatitis C virus (HCV) genotype 1a and 3a partial NS5B gene segment sequences obtained from 154 HCV-infected injection drug users were studied to determine the extent to which HCV transmission occurs between injection drug user communities in London, Edinburgh, Glasgow (United Kingdom), Marseilles (France), and Melbourne. Phylogenetic relationships between sequences were analyzed by conventional methods and by a recently developed method that numerically scores the extent of sequence segregation between groups through calculation of association indices. The association indices revealed that none of the cities sampled support an HCV population that is completely isolated from that circulating in the other cities. Sequences from Melbourne were most isolated, whereas those from London were most dispersed. This suggests that HCV transmission between these cities occurs, with London playing a pivotal role. The degree of city-specific segregation of HCV subtype 1a sequences was linearly related to that of subtype 3a, indicating that these subtypes have spread through similar transmission networks.

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