The Chemokine System in Neuroinflammation: An Update | Zendy

Richard M. Ransohoff | Zendy

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The Chemokine System in Neuroinflammation: An Update

Author(s) -

Richard M. Ransohoff

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/344266

Subject(s) - chemokine , neuroinflammation , chemokine receptor , central nervous system , immunology , multiple sclerosis , inflammation , biology , leukocyte trafficking , infiltration (hvac) , neuroscience , physics , thermodynamics

Chemokines and their receptors govern physiologic and pathologic leukocyte trafficking. The function of the chemokine system may be of particular interest for hematogenous leukocyte infiltration of the central nervous system (CNS) because of the distinct character of CNS inflammation and the exquisite specificity with which the chemokine system regulates cellular migration events. This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes. Animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis are both considered.

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