Open AccessCognitive Impairment in Adults with Good Recovery after Bacterial Meningitis
Author(s) -
Diederik van de Beek,
Ben Schmand,
Jan de Gans,
Martijn Weisfelt,
Heleen Vaessen,
Jacob Dankert,
Marinus Vermeulen
Publication year - 2002
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/344229
Subject(s) - meningitis , medicine , pediatrics , prospective cohort study , streptococcus pneumoniae , neuropsychology , neisseria meningitidis , cohort , glasgow outcome scale , cognition , psychiatry , glasgow coma scale , biology , bacteria , genetics
Adults without neurologic sequelae after bacterial meningitis are supposed to live without restrictions. Neuropsychological outcome was assessed in 51 adults from a prospective cohort with good recovery, defined as Glasgow Outcome Scale score 5, after pneumococcal or meningococcal meningitis. Patients who recovered well after pneumococcal meningitis showed cognitive slowness (P=.001). A cognitive disorder was found in 27% of these patients. Patients who previously had meningococcal meningitis were not significantly different from control subjects. Scores on general health and quality of life questionnaires revealed lower scores for patients with meningitis, which were related to cognitive slowing (R, -0.46 to -0.38). In conclusion, adults surviving pneumococcal meningitis were at significant risk of neuropsychological abnormalities, even if they were clinically well recovered.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom