Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients | Zendy

Nell S. Lurain | Zendy; Sangeeta Bhorade | Zendy; Kenneth Pursell | Zendy; Robin K. Avery | Zendy; Vijay Yeldandi | Zendy; Carlos M. Isada | Zendy; Emmanuel S. Robert | Zendy; Debra Kohn | Zendy; Max Q. Arens | Zendy; Edward R. Garrity | Zendy; Alan Taege | Zendy; Martin G. Mullen | Zendy; Kathleen Todd | Zendy; James W. Bremer | Zendy; Belinda YenLieberman | Zendy

Open Access

Analysis and Characterization of Antiviral Drug–Resistant Cytomegalovirus Isolates from Solid Organ Transplant Recipients

Author(s) -

Nell S. Lurain,

Sangeeta Bhorade,

Kenneth Pursell,

Robin K. Avery,

Vijay Yeldandi,

Carlos M. Isada,

Emmanuel S. Robert,

Debra Kohn,

Max Q. Arens,

Edward R. Garrity,

Alan Taege,

Martin G. Mullen,

Kathleen Todd,

James W. Bremer,

Belinda YenLieberman

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/342844

Subject(s) - drug resistance , cytomegalovirus , biology , population , virology , organ transplantation , immunology , drug , polymerase chain reaction , transplantation , virus , medicine , viral disease , herpesviridae , gene , microbiology and biotechnology , pharmacology , genetics , environmental health

The development of cytomegalovirus (CMV) disease and subsequent emergence of drug-resistant strains was examined in a large group of solid organ transplant recipients; drug-resistant CMV was detected in a total of 30 transplant recipients (20 lung, 5 kidney, 4 heart, and 1 liver). Drug resistance was confirmed both phenotypically and genotypically. The sequences of drug-resistant CMV strains from the same patient differed from drug-susceptible baseline sequences only at single sites previously confirmed to confer drug resistance. At least 1 isolate from each patient had a mutation in the UL97 phosphotransferase coding sequence. Mutations in the DNA polymerase gene were found in 6 of 38 sequenced strains. Lung transplant recipients had the highest incidence of drug-resistant virus: of the 30 patients, 28 were CMV-seronegative transplant recipients of CMV-seropositive organs, which strongly supports the premise that drug resistance is most prevalent in that transplant population.

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