Human Herpesvirus 8–Positive Castleman Disease in Human Immunodeficiency Virus–Infected Patients: The Impact of Highly Active Antiretroviral Therapy | Zendy

Laurent Aaron | Zendy; Olivier Lidove | Zendy; Chérine Yousry | Zendy; Laurent Roudière | Zendy; B. Dupont | Zendy; Jean Paul Viard | Zendy

Open Access

Human Herpesvirus 8–Positive Castleman Disease in Human Immunodeficiency Virus–Infected Patients: The Impact of Highly Active Antiretroviral Therapy

Author(s) -

Laurent Aaron,

Olivier Lidove,

Chérine Yousry,

Laurent Roudière,

B. Dupont,

Jean Paul Viard

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/342696

Subject(s) - medicine , immunopathology , viral disease , antiretroviral therapy , disease , sida , castleman disease , chemotherapy , human immunodeficiency virus (hiv) , immune system , immunology , virus , lentivirus , virology , viral load

We report the case histories of 7 human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) who had a diagnosis of Castleman disease. All 6 patients who were treated responded to chemotherapy; immune reconstitution was observed in 5 patients, but it did not prevent relapse of Castleman disease. However, the mean duration of survival observed in this series (48 months) was most probably due to immune reconstitution resulting from receipt of HAART, which reduced the mortality associated with HIV disease.

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