Open AccessHuman Papillomavirus Type 16 Intratypic Variant Infection and Risk for Cervical Neoplasia in Southern China
Author(s) -
Paul K.S. Chan,
Ching Wan Lam,
Tak Hong Cheung,
William W H Li,
Keith W.K. Lo,
May Y.M. Chan,
Jo L.K. Cheung,
L. Y. Xu,
Augustine F. Cheng
Publication year - 2002
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/342048
Subject(s) - human papillomavirus , cervical cancer , epidemiology , hpv infection , lineage (genetic) , cervical intraepithelial neoplasia , biology , virology , medicine , gene , oncology , genetics , cancer
A case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. No increased risk was observed for the subclasses European variant and European 350G, which carry a higher risk for invasive cancer in some Western populations. The E7 N29S substitution, reported to have a higher risk in Korean women, was found equally distributed among normal and various degrees of neoplasia. The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world.
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