Immune Reconstitution Syndrome after Successful Treatment ofPneumocystis cariniiPneumonia in a Man with Human Immunodeficiency Virus Type 1 Infection | Zendy

Christine Koval | Zendy; Francis Gigliotti | Zendy; Diana L. Nevins | Zendy; Lisa M. Demeter | Zendy

Open Access

Immune Reconstitution Syndrome after Successful Treatment ofPneumocystis cariniiPneumonia in a Man with Human Immunodeficiency Virus Type 1 Infection

Author(s) -

Christine Koval,

Francis Gigliotti,

Diana L. Nevins,

Lisa M. Demeter

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/341974

Subject(s) - pneumocystis carinii , medicine , pneumonia , immune system , immune reconstitution inflammatory syndrome , immunopathology , immunology , lung , respiratory disease , virology , virus , pneumocystis jirovecii , viral load , antiretroviral therapy

We describe a 34-year-old man with human immunodeficiency virus infection who received successful treatment of minimally symptomatic Pneumocystis carinii pneumonia and who subsequently developed diffuse pulmonary infiltrates and hypoxia 2 weeks after initiation of combination antiretroviral therapy. Initial pathologic evaluation of lung-tissue samples revealed no organisms, but a polymerase chain reaction assay was strongly positive for P. carinii DNA. We hypothesize that this patient's clinical presentation denotes immune reconstitution syndrome in response to residual P. carinii antigen in the lung.

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