Selection of Cefoxitin‐ResistantBacteroides thetaiotaomicronMutants and Mechanisms Involved in β‐Lactam Resistance | Zendy

Hong Fang | Zendy; Charlotta Edlund | Zendy; Carl Erik Nord | Zendy; Maria Hedberg | Zendy

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Selection of Cefoxitin‐ResistantBacteroides thetaiotaomicronMutants and Mechanisms Involved in β‐Lactam Resistance

Author(s) -

Hong Fang,

Charlotta Edlund,

Carl Erik Nord,

Maria Hedberg

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/341920

Subject(s) - cefoxitin , bacteroides thetaiotaomicron , microbiology and biotechnology , bacteroides fragilis , bacteroides , penicillin , penicillin binding proteins , cephalosporin , antibiotics , bacteroidaceae , mutant , bacterial outer membrane , biology , bacteria , gene , escherichia coli , genetics , staphylococcus aureus

The beta-lactam antibiotics are the most widely used of all the groups of antimicrobials, but beta-lactam resistance is increasingly common among members of the Bacteroides fragilis group. Three major mechanisms are involved in beta-lactam resistance, and they act together in certain instances. In the present study, 2 resistant mutants (238m and 1186m) of Bacteroides thetaiotaomicron, obtained from clinical isolates (238 and 1186) by selection with increasing concentrations of cefoxitin, showed decreased susceptibilities to cefoxitin and other beta-lactam antibiotics. Alterations in both penicillin-binding proteins (PBPs) and outer-membrane proteins (OMPs) were observed in the mutants in comparison with their parent strains. The similar alteration in OMPs was also observed in clinical isolates. In conclusion, the beta-lactam-resistant mutants of B. thetaiotaomicron with deficiency in both PBPs and OMPs can be selected for by exposure to cefoxitin, and several mechanisms are involved in the beta-lactam resistance in the strains investigated.

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