Epidemiology of Invasive Group AStreptococcusDisease in the United States, 1995–1999 | Zendy

Katherine L. O’Brien | Zendy; Bernard Beall | Zendy; Nancy L. Barrett | Zendy; Paul R. Cieslak | Zendy; Arthur Reingold | Zendy; Monica M. Farley | Zendy; Richard Danila | Zendy; Elizabeth R. Zell | Zendy; Richard R. Facklam | Zendy; Benjamin Schwartz | Zendy; Anne Schuchat | Zendy

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Epidemiology of Invasive Group AStreptococcusDisease in the United States, 1995–1999

Author(s) -

Katherine L. O’Brien,

Bernard Beall,

Nancy L. Barrett,

Paul R. Cieslak,

Arthur Reingold,

Monica M. Farley,

Richard Danila,

Elizabeth R. Zell,

Richard R. Facklam,

Benjamin Schwartz,

Anne Schuchat

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/341409

Subject(s) - medicine , epidemiology , pneumonia , meningitis , streptococcus , toxic shock syndrome , population , disease , incidence (geometry) , streptococcus pyogenes , demography , mortality rate , pediatrics , environmental health , staphylococcus aureus , biology , bacteria , genetics , physics , sociology , optics

Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10-20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of invasive GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or >/=65 years old), surveillance area, and race (higher among black individuals) but did not increase during the study period. The 5 most common emm types (1, 28, 12, 3, and 11) accounted for 49.2% of isolates; newly characterized emm types accounted for 8.9% of isolates. Older age; presence of streptococcal toxic shock syndrome, meningitis, or pneumonia; and infection with emm1 or emm3 were all independent predictors of death. We estimate that 9600-9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100-1300 deaths.

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