Hypophyseal Hemorrhage and Panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and Detection of Viral Antigen in the Hypophysis | Zendy

Timo Hautala | Zendy; Tarja Sironen | Zendy; Olli Vapalahti | Zendy; Eija Pääkkö | Zendy; Terttu Särkioja | Zendy; Pasi Salmela | Zendy; Antti Vaheri | Zendy; Alexander Plyusnin | Zendy; Heikki Kauma | Zendy

Open Access

Hypophyseal Hemorrhage and Panhypopituitarism during Puumala Virus Infection: Magnetic Resonance Imaging and Detection of Viral Antigen in the Hypophysis

Author(s) -

Timo Hautala,

Tarja Sironen,

Olli Vapalahti,

Eija Pääkkö,

Terttu Särkioja,

Pasi Salmela,

Antti Vaheri,

Alexander Plyusnin,

Heikki Kauma

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/340859

Subject(s) - puumala virus , medicine , magnetic resonance imaging , pathology , hantavirus , virus , autopsy , virology , radiology

We describe 3 cases of nephropathia epidemica (NE) that confirm that Puumala virus infection may cause hypophyseal injury. Autopsy revealed a hemorrhagic hypophysis positive for Puumala virus antigen in both neuroendocrine stromal and vascular endothelial cells in 1 patient, and 2 patients developed hypophyseal hemorrhage (diagnosed with magnetic resonance imaging) during or shortly after acute NE, both of whom developed panhypopituitarism.

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