Relative Infectivity of Hepatitis A Virus by the Oral and Intravenous Routes in 2 Species of Nonhuman Primates | Zendy

Robert H. Purcell | Zendy; Doris C. Wong | Zendy; Max Shapiro | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Relative Infectivity of Hepatitis A Virus by the Oral and Intravenous Routes in 2 Species of Nonhuman Primates

Author(s) -

Robert H. Purcell,

Doris C. Wong,

Max Shapiro

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/340520

Subject(s) - infectivity , virology , hepatitis a virus , feces , virus , virulence , oral route , hepatitis a , hepatitis , medicine , biology , immunology , microbiology and biotechnology , pharmacology , biochemistry , gene

Hepatitis A virus (HAV) is naturally transmitted by the fecal-oral route but can also be transmitted intravenously. To determine the relative infectivity of these 2 routes, an infectivity titration of a standard challenge pool of virulent HAV was performed in tamarins and chimpanzees. In both species, 1 oral dose of HAV was equivalent to 10(4.5) intravenous doses. These findings have relevance for attempts to develop live, attenuated HAV vaccines that can be administered orally.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research