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Epidemic Canadian methicillin-resistant Staphylococcus aureus strain 1 (CMRSA-1) comprises related subtypes that differ in phenotype and prevalence, with subtypes 1A, 1B, and 1D representing 1%, 71%, and 18%, respectively, of total CMRSA-1 isolates. The predominant CMRSA-1B subtype possesses a variant of the staphylococcal cassette chromosome mec, harboring pls, which encodes plasmin-sensitive surface protein (Pls). CMRSA-1B cells that express Pls exhibited poor adhesion to keratinocyte extracellular matrix. However, CMRSA-1B and purified Pls adhered to cellular lipids and glycolipids, and Pls promoted bacterial cell-cell interactions. Although exoprotein expression was restricted to a precursor form of lipase in CMRSA-1B, it was not attenuated in virulence relative to CMRSA-1A, which exhibits normal exoprotein expression. In contrast, CMRSA-1D exhibited a pleiotropic defect in exoprotein expression and attenuated virulence relative to CMRSA-1A. These data indicate that the high transmissibility of CMRSA-1B was not achieved at the expense of attenuated virulence and that Pls confers a novel adhesion mechanism.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Adhesion and Virulence Properties of Epidemic Canadian Methicillin‐Resistant<i>Staphylococcus aureus</i>Strain 1: Identification of Novel Adhesion Functions Associated with Plasmin‐Sensitive Surface Protein

Adhesion and Virulence Properties of Epidemic Canadian Methicillin‐ResistantStaphylococcus aureusStrain 1: Identification of Novel Adhesion Functions Associated with Plasmin‐Sensitive Surface Protein