Emergence of Multiple Drug‐Resistant Human Cytomegalovirus Variants in 2 Patients with Human Immunodeficiency Virus Infection Unresponsive to Highly Active Antiretroviral Therapy | Zendy

Fausto Baldanti | Zendy; Stefania Paolucci | Zendy; Aldo Parisi | Zendy; Luca Meroni | Zendy; Giuseppe Gerna | Zendy

Open Access

Emergence of Multiple Drug‐Resistant Human Cytomegalovirus Variants in 2 Patients with Human Immunodeficiency Virus Infection Unresponsive to Highly Active Antiretroviral Therapy

Author(s) -

Fausto Baldanti,

Stefania Paolucci,

Aldo Parisi,

Luca Meroni,

Giuseppe Gerna

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/339750

Subject(s) - human cytomegalovirus , virology , medicine , cytomegalovirus , drug resistance , antiretroviral therapy , human immunodeficiency virus (hiv) , drug , lentivirus , cytomegalovirus retinitis , virus , sida , viral disease , immunology , retinitis , viral replication , herpesviridae , viral load , biology , microbiology and biotechnology , pharmacology

In 2 patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy was unable to suppress HIV replication as a result of the emergence of drug-resistant HIV variants. Human cytomegalovirus (HCMV) retinitis developed in both patients, and an unusually complex mixture of drug-resistant HCMV variants was detected in both patients.

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