Hepatitis A Virus Infection in Tamarins: Experimental Transmission via Contaminated Factor VIII Concentrates | Zendy

Michael Chudy | Zendy; Christiane StahlHennig | Zendy; Annemarie Berger | Zendy; C. Micha Nübling | Zendy; Gerhard Hunsmann | Zendy; Holger F. Rabenau | Zendy; Johannes Löwer | Zendy

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Hepatitis A Virus Infection in Tamarins: Experimental Transmission via Contaminated Factor VIII Concentrates

Author(s) -

Michael Chudy,

Christiane StahlHennig,

Annemarie Berger,

C. Micha Nübling,

Gerhard Hunsmann,

Holger F. Rabenau,

Johannes Löwer

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/339683

Subject(s) - seroconversion , virology , feces , outbreak , hepatitis a , biology , hepatitis a virus , transmission (telecommunications) , virus , microbiology and biotechnology , immunology , hepatitis , electrical engineering , engineering

An experimental hepatitis A virus (HAV) transmission study was performed in 3 tamarins, using a factor VIII concentrate linked to a recent outbreak of HAV infections in German hemophiliacs. The typical indicators for HAV infection were investigated in feces and serum samples. One tamarin showed a classical HAV infection with seroconversion. HAV antigen and HAV RNA were detected in feces of a second animal, but no seroconversion was observed until 19 weeks after inoculation. The HAV sequences from the reverse-transcription- and polymerase chain reaction-positive samples of the 2 animals were identical to the deduced HAV sequences of the chain of infection (from plasma pool to final product to patients). The study results provide conclusive evidence of the presence of infectious HAV in coagulation factor concentrate. Because a number of HAV transmission episodes have been described for solely solvent/detergent-treated factor VIII preparations, continued use of these agents seems questionable.

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