Open AccessChanges in the Plasma Lipid Profile as a Potential Predictor of Clinical Outcome in Dengue Hemorrhagic Fever
Author(s) -
Eric C. M. Van Gorp,
Catharina Suharti,
Albert T.A. Mairuhu,
W.M.V. Dolmans,
Johanna van der Ven,
Pierre N.M. Demacker,
J.W.M. van der Meer
Publication year - 2002
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/339539
Subject(s) - dengue fever , medicine , dengue hemorrhagic fever , lipid profile , intensive care unit , gastroenterology , total cholesterol , lipoprotein , immunology , cholesterol , dengue virus
In 50 consecutive children admitted to the intensive care unit with the clinical diagnosis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (grade III or IV), 20 patients with mild DHF (grade I or II), and 20 healthy control patients, the plasma lipid profile was measured. Levels of total plasma cholesterol, high-density lipoprotein, and low-density lipoprotein were significantly decreased in patients with the severest cases, compared with patients with mild DHF and healthy controls. Changes in the plasma lipid profile differentiate between patients with different stages of DHF disease severity and could be used as a potential predictor for clinical outcome.
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