Nosocomial Bloodstream Infections among Human Immunodeficiency Virus-Infected Patients: Incidence and Risk Factors | Zendy

Nicola Petrosillo | Zendy; Pierluigi Viale | Zendy; Emanuele Nicastri | Zendy; Claudio Arici | Zendy; Enrico Bombana | Zendy; Antonio José Montoya Casella | Zendy; Francesco Cristini | Zendy; M. De Gennaro | Zendy; Ferdinando Dodi | Zendy; Andrea Gabbuti | Zendy; Gianni Gattuso | Zendy; Laura Irato | Zendy; Paolo Maggi | Zendy; Federica Pallavicini | Zendy; Alexander Pan | Zendy; M. Pantaleoni | Zendy; Giuseppe Ippolito | Zendy

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Nosocomial Bloodstream Infections among Human Immunodeficiency Virus-Infected Patients: Incidence and Risk Factors

Author(s) -

Nicola Petrosillo,

Pierluigi Viale,

Emanuele Nicastri,

Claudio Arici,

Enrico Bombana,

Antonio José Montoya Casella,

Francesco Cristini,

M. De Gennaro,

Ferdinando Dodi,

Andrea Gabbuti,

Gianni Gattuso,

Laura Irato,

Paolo Maggi,

Federica Pallavicini,

Alexander Pan,

M. Pantaleoni,

Giuseppe Ippolito

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/338813

Subject(s) - medicine , incidence (geometry) , bloodstream infection , central venous catheter , prospective cohort study , bacteremia , multivariate analysis , human immunodeficiency virus (hiv) , catheter , intensive care medicine , pediatrics , surgery , immunology , antibiotics , physics , optics , biology , microbiology and biotechnology

To assess the incidence of nosocomial bloodstream infections (NBSIs) in human immunodeficiency virus (HIV)-infected patients, and to analyze the main associated risk factors, we performed a 1-year multicenter prospective study of patients with advanced HIV infection who were consecutively admitted to 17 Italian infectious diseases wards. As of May 1999, a total of 65 NBSIs (4.7%) occurred in 1379 admissions, for an incidence of 2.45 NBSIs per 1000 patient-days. Twenty-nine NBSIs were catheter-related bloodstream infections, with a rate of 9.6 central venous catheter-associated infections per 1000 device-days. Multivariate analysis indicated that variables independently associated with NBSIs included active injection drug use, a Karnofsky Performance Status score of <40, presence of a central venous catheter, and length of hospital stay. Mortality rates were 24.6% and 7.2% among patients with and without NBSIs, respectively (P<.00001). In the era of highly active antiretroviral therapy, NBSIs continue to occur frequently and remain severe and life-threatening manifestations.

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