Ferrets as a Model System for Renal Disease Secondary to Intestinal Infection withEscherichia coliO157:H7 and Other Shiga Toxin–ProducingE. coli | Zendy

Jon B. Woods | Zendy; Clare K. Schmitt | Zendy; Stephen C. Darnell | Zendy; Karen C. Meysick | Zendy; Alison D. O’Brien | Zendy

Open Access

Ferrets as a Model System for Renal Disease Secondary to Intestinal Infection withEscherichia coliO157:H7 and Other Shiga Toxin–ProducingE. coli

Author(s) -

Jon B. Woods,

Clare K. Schmitt,

Stephen C. Darnell,

Karen C. Meysick,

Alison D. O’Brien

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/338633

Subject(s) - shiga toxin , escherichia coli , microbiology and biotechnology , shiga like toxin , toxin , biology , virology , genetics , gene

Ferrets were evaluated as a possible small animal model for the development of colitis and/or signs of the hemolytic uremic syndrome after oral infection with Escherichia coli O157:H7 or other Shiga toxin--producing E. coli (STEC). Ferrets treated with streptomycin (Stm) had higher counts of E. coli O157:H7 strain 86-24 Stm-resistant (Stm(r)) or O91:H21 strain B2F1 Stm(r) in their stools than non--Stm-treated animals. None of the animals displayed evidence of colitis, but Stm-treated animals fed strain 86-24 Stm(r) exhibited weight loss significantly greater than that exhibited by ferrets fed an isogenic mutant negative for the adhesin intimin. Moreover, 11 (23%) of the 47 Stm-treated ferrets inoculated with 86-24 Stm(r) or B2F1 Stm(r) developed hematuria and/or histological damage to glomeruli or thrombocytopenia, compared with 0 of 14 uninfected control animals receiving Stm in water. Thus, the ferret may serve as a model for renal disease secondary to intestinal infection with STEC.

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