CD154 and Type‐1 Cytokine Response: From Hyper IgM Syndrometo Human Immunodeficiency Virus Infection | Zendy

Carlos S. Subauste | Zendy

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CD154 and Type‐1 Cytokine Response: From Hyper IgM Syndrometo Human Immunodeficiency Virus Infection

Author(s) -

Carlos S. Subauste

Publication year - 2002

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/338003

Subject(s) - cd154 , cd40 , immunology , immunosuppression , virology , toxoplasma gondii , biology , cytokine , immune system , antibody , cytotoxic t cell , in vitro , biochemistry

CD40 and CD154 (CD40 ligand) are surface molecules that are central to the cross-talk between T cells and antigen-presenting cells. This article reviews the relevance of CD40-CD154 interaction for regulation of interleukin-12/interferon-gamma production in response to Toxoplasma gondii as an example of an intracellular pathogen. The manner in which defects in CD154 signaling contribute to immunosuppression and susceptibility to opportunistic infections in patients with X-linked hyper IgM syndrome and in patients with human immunodeficiency virus infection is also discussed.

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