Risk Factors for Development of Tuberculosis after Isoniazid Chemoprophylaxis in Human Immunodeficiency Virus--Infected Patients | Zendy

José L. Casado | Zendy; Santiago Moreno | Zendy; Jesús Fortün | Zendy; Antonio Antela | Zendy; C. Quereda | Zendy; E Navas | Zendy; A. Moreno | Zendy; Fernando Dronda | Zendy

Open Access

Risk Factors for Development of Tuberculosis after Isoniazid Chemoprophylaxis in Human Immunodeficiency Virus--Infected Patients

Author(s) -

José L. Casado,

Santiago Moreno,

Jesús Fortün,

Antonio Antela,

C. Quereda,

E Navas,

A. Moreno,

Fernando Dronda

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/324746

Subject(s) - chemoprophylaxis , medicine , isoniazid , tuberculosis , confidence interval , hazard ratio , immunology , pediatrics , pathology

The long-term benefit of isoniazid chemoprophylaxis in human immunodeficiency virus (HIV)-infected patients and risk factors for isoniazid failure were studied in 131 HIV-infected patients who received >9 months of isoniazid preventive therapy. During a median follow-up of 43 months, 8 patients developed tuberculosis (TB) (6%; 0.61 cases per 100 patient-years). Only the persistence of risk factors for exposure to TB was statistically associated with development of disease (relative hazard, 3.17; 95% confidence interval, 1.56-17; P<.001). Our data suggest reinfection as the main cause of TB after isoniazid prophylaxis.

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