Chagasic Meningoencephalitis in a Patient with Acquired Immunodeficiency Syndrome: Diagnosis, Follow-Up, and Genetic Characterization of Trypanosoma cruzi | Zendy

E. LagesSilva | Zendy; Luı́s Eduardo Ramı́rez | Zendy; Mário León Silva-Vergara | Zendy; Égler Chiari | Zendy

Open Access

Chagasic Meningoencephalitis in a Patient with Acquired Immunodeficiency Syndrome: Diagnosis, Follow-Up, and Genetic Characterization of Trypanosoma cruzi

Author(s) -

E. LagesSilva,

Luı́s Eduardo Ramı́rez,

Mário León Silva-Vergara,

Égler Chiari

Publication year - 2002

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/324355

Subject(s) - trypanosoma cruzi , meningoencephalitis , chagas disease , kinetoplast , polymerase chain reaction , virology , medicine , cerebrospinal fluid , immunology , biology , parasite hosting , pathology , dna , genetics , gene , world wide web , computer science

Early diagnosis of the clinical reactivation of Chagas' disease in human immunodeficiency virus- and Trypanosoma cruzi-coinfected persons is fundamental for a good prognosis. Polymerase chain reaction rapidly and efficiently demonstrated the presence and elimination of T. cruzi in the cerebrospinal fluid of a patient with chagasic meningoencephalitis. Characterization of T. cruzi, directly and indirectly in blood and cerebrospinal fluid samples, demonstrated homogeneity of kinetoplast DNA and the presence of lineage 1 (T. cruzi II) in both parasite populations.

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