Secreted Virus–Encoded Proteins Reflect Murine Cytomegalovirus Productivity in Organs | Zendy

Wolfram Brune | Zendy; Milena Hasan | Zendy; M. Krych | Zendy; Ivan Bubić | Zendy; Stipan Jonjić | Zendy; U H Koszinowski | Zendy

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Secreted Virus–Encoded Proteins Reflect Murine Cytomegalovirus Productivity in Organs

Author(s) -

Wolfram Brune,

Milena Hasan,

M. Krych,

Ivan Bubić,

Stipan Jonjić,

U H Koszinowski

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/323993

Subject(s) - viremia , virology , biology , human cytomegalovirus , virus , cytomegalovirus , recombinant dna , betaherpesvirinae , herpesviridae , immunology , viral disease , gene , genetics

Mouse infection with murine cytomegalovirus (MCMV) is an established model for studying human cytomegalovirus infection. In this study, the relationship was analyzed between MCMV activity in organs of infected mice and the presence of infectious virus (viremia), viral genomes (DNAemia), or secreted virus-encoded proteins in the blood. For the latter, 2 recombinant viruses were constructed that encode for the hepatitis B virus surface antigen and the secreted alkaline phosphatase, respectively, as secreted marker proteins. The secreted markers correlated better with the infection in organs than DNAemia and viremia. The marker protein assays can serve as practical and sensitive tools for longitudinal monitoring of MCMV infection in individual mice.

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