Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes | Zendy

Francesco Dieli | Zendy; Marita TroyeBlomberg | Zendy; Juraj Iványi | Zendy; JeanJacques Fournié | Zendy; Alan M. Krensky | Zendy; Marc Bonneville | Zendy; Marie Alix Peyrat | Zendy; Nadia Caccamo | Zendy; Guido Sireci | Zendy; Alfredo Salerno | Zendy

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Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes

Author(s) -

Francesco Dieli,

Marita TroyeBlomberg,

Juraj Iványi,

JeanJacques Fournié,

Alan M. Krensky,

Marc Bonneville,

Marie Alix Peyrat,

Nadia Caccamo,

Guido Sireci,

Alfredo Salerno

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/323600

Subject(s) - granulysin , mycobacterium tuberculosis , intracellular , extracellular , microbiology and biotechnology , perforin , intracellular parasite , tuberculosis , immune system , biology , t lymphocyte , immunology , virology , medicine , cd8 , pathology

Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.

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