Complement C4 Deficiency and HLA Homozygosity in Patients with Frequent Intraoral Herpes Simplex Virus Type 1 Infections | Zendy

Mikko Seppänen | Zendy; MarjaLiisa Lokki | Zendy; Tuomo Timonen | Zendy; Maija Lappalainen | Zendy; Hanna Jarva | Zendy; Asko Järvinen | Zendy; Seppo Sarna | Zendy; Ville Valtonen | Zendy; Seppo Meri | Zendy

Open Access

Complement C4 Deficiency and HLA Homozygosity in Patients with Frequent Intraoral Herpes Simplex Virus Type 1 Infections

Author(s) -

Mikko Seppänen,

MarjaLiisa Lokki,

Tuomo Timonen,

Maija Lappalainen,

Hanna Jarva,

Asko Järvinen,

Seppo Sarna,

Ville Valtonen,

Seppo Meri

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/323462

Subject(s) - herpes simplex virus , medicine , complement deficiency , immunology , human leukocyte antigen , virology , virus , complement (music) , herpesviridae , antibody , antigen , complement system , viral disease , biology , complementation , gene , phenotype , biochemistry

Three consecutive patients with no apparent immunodeficiency who had frequent intraoral herpes simplex type 1 recurrences, a rare complication of herpes simplex virus infection, were found to have a total deficiency of either the A or B isotype of the complement component C4 and to be homozygous for the studied HLA antigens. A combination of HLA homozygosity, which may lead to impaired T cell recognition of viral peptides, and deficiency in the classical complement pathway, which can compromise virus neutralization, may predispose to severe and frequent herpes simplex virus infections.

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