Yield of Large‐Volume Blood Cultures in Patients with Early Lyme Disease | Zendy

Gary P. Wormser | Zendy; Susan Bittker | Zendy; Denise R. Cooper | Zendy; John Nowakowski | Zendy; Robert B. Nadelman | Zendy; Charles S. Pavia | Zendy

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Yield of Large‐Volume Blood Cultures in Patients with Early Lyme Disease

Author(s) -

Gary P. Wormser,

Susan Bittker,

Denise R. Cooper,

John Nowakowski,

Robert B. Nadelman,

Charles S. Pavia

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/323424

Subject(s) - lyme disease , borrelia burgdorferi , erythema , blood culture , erythema migrans , medicine , spirochaetaceae , blood volume , yield (engineering) , immunology , biology , microbiology and biotechnology , antibiotics , antibody , lyme borreliosis , materials science , metallurgy

To improve yield, 6 3-mL plasma cultures (18 mL total) were established for adult patients with early Lyme disease associated with erythema migrans. Borrelia burgdorferi was recovered from the blood of 22 (44.0%) of 50 evaluable patients. The recovery rate per plasma culture and the frequency of positive results for plasma cultures for individual patients were consistent with a level of spirochetemia of approximately 0.1 cultivable cell/mL of whole blood. Our findings suggest that, if further improvements in the yield of blood cultures are possible, they probably will depend on enhancing the sensitivity of the culture method rather than increasing the volume of material cultured.

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