Cerebrospinal Fluid Penetration of Levofloxacin in Patients with Spontaneous Acute Bacterial Meningitis | Zendy

Piergiorgio Scotton | Zendy; Federico Pea | Zendy; Mario Giobbia | Zendy; Massimo Baraldo | Zendy; A. Vaglia | Zendy; Mario Furlanut | Zendy

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Cerebrospinal Fluid Penetration of Levofloxacin in Patients with Spontaneous Acute Bacterial Meningitis

Author(s) -

Piergiorgio Scotton,

Federico Pea,

Mario Giobbia,

Massimo Baraldo,

A. Vaglia,

Mario Furlanut

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/323406

Subject(s) - medicine , levofloxacin , cerebrospinal fluid , meningitis , bacterial meningitis , penetration (warfare) , microbiology and biotechnology , antibiotics , surgery , pathology , operations research , biology , engineering

We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99+/-0.67 microg/mL, and the C(L)/C(P) at 2 hours after dosing was 0.34+/-0.09.

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