Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance | Zendy

Susan K. Seo | Zendy; Anne D. Regan | Zendy; Tomáš Cihlář | Zendy; Deborah C. Lin | Zendy; Farid Boulad | Zendy; Diane George | Zendy; Vinod K. Prasad | Zendy; Timothy E. Kiehn | Zendy; Bruce Polsky | Zendy

Open Access

Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance

Author(s) -

Susan K. Seo,

Anne D. Regan,

Tomáš Cihlář,

Deborah C. Lin,

Farid Boulad,

Diane George,

Vinod K. Prasad,

Timothy E. Kiehn,

Bruce Polsky

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/323022

Subject(s) - foscarnet , medicine , ganciclovir , viremia , bone marrow transplant , cytomegalovirus retinitis , cytomegalovirus , retinitis , human cytomegalovirus , drug resistance , virology , bone marrow , viral disease , immunology , betaherpesvirinae , bone marrow transplantation , herpesviridae , virus , microbiology and biotechnology , biology

We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

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