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Emergence of Rifampin‐ResistantStreptococcus pneumoniaeas a Result of Antimicrobial Therapy for Penicillin‐Resistant Strains
Author(s) -
Peter M.B. van Tilburg,
Debby Bogaert,
Marcel Sluijter,
A Jansz,
Ronald de Groot,
Peter W. M. Hermans
Publication year - 2001
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/323021
Subject(s) - medicine , streptococcus pneumoniae , ceftriaxone , penicillin , microbiology and biotechnology , antimicrobial , outbreak , multiple drug resistance , antibiotics , virology , biology
A multidrug-resistant strain of Streptococcus pneumoniae was isolated in The Netherlands during a nosocomial outbreak among 36 patients who mainly had chronic obstructive pulmonary disease. After the commencement of barrier nursing and short-term ceftriaxone-rifampin eradication therapy, the epidemic ceased. However, eradication therapy failed in 3 patients, and follow-up investigation of these patients showed the emergence of rifampin-resistant isolates.

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