Local Production of Anti–Vibrio choleraeMucosal Antibody in Reproductive Tract Tissues after Cholera | Zendy

Edward T. Ryan | Zendy; Emily A. Bridges | Zendy; Thomas I. Crean | Zendy; Kaniz Gausia | Zendy; Jena Hamadani | Zendy; Ayesha Aziz | Zendy; Sarah Hawkes | Zendy; Monira Begum | Zendy; J Bogaerts | Zendy; Shah M. Faruque | Zendy; Mohammed Abdus Salam | Zendy; George J. Fuchs | Zendy; Stephen B. Calderwood | Zendy

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Local Production of Anti–Vibrio choleraeMucosal Antibody in Reproductive Tract Tissues after Cholera

Author(s) -

Edward T. Ryan,

Emily A. Bridges,

Thomas I. Crean,

Kaniz Gausia,

Jena Hamadani,

Ayesha Aziz,

Sarah Hawkes,

Monira Begum,

J Bogaerts,

Shah M. Faruque,

Mohammed Abdus Salam,

George J. Fuchs,

Stephen B. Calderwood

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/322807

Subject(s) - vibrio cholerae , cholera toxin , microbiology and biotechnology , immune system , biology , immunoglobulin a , antibody , cholera , antigen , immunology , cholera vaccine , vibrionaceae , immunoglobulin g , virology , bacteria , genetics

To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P< or =.02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P< or =.001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

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