Impaired Antifungal Effector Activity but Not Inflammatory Cell Recruitment in Interleukin‐6–Deficient Mice with Invasive Pulmonary Aspergillosis | Zendy

Elio Cenci | Zendy; Antonella Mencacci | Zendy; Andrea Casagrande | Zendy; Paolo Mosci | Zendy; Francesco Bistoni | Zendy; Luigina Romani | Zendy

Open Access

Impaired Antifungal Effector Activity but Not Inflammatory Cell Recruitment in Interleukin‐6–Deficient Mice with Invasive Pulmonary Aspergillosis

Author(s) -

Elio Cenci,

Antonella Mencacci,

Andrea Casagrande,

Paolo Mosci,

Francesco Bistoni,

Luigina Romani

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/322793

Subject(s) - aspergillus fumigatus , effector , aspergillosis , immunology , biology , microbiology and biotechnology , mycosis , antifungal , immunity , immune system

A murine model of infection, in which immunocompetent or immunosuppressed interleukin-6-deficient (IL-6(-/-)) mice were infected intranasally with Aspergillus fumigatus conidia and were monitored for parameters of fungal colonization and innate and adaptive immunity, was used to assess the role of IL-6 in invasive pulmonary aspergillosis (IPA). The results indicate that IL-6(-/-) mice were more susceptible than wild-type mice to IPA. Susceptibility was associated with increased inflammatory pathology, decreased antifungal effector functions of phagocytes, and impaired development of protective type 1 responses. Exposure to exogenous IL-6 restored antifungal effector activity.

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