English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The transepithelial migration of Escherichia coli that expressed all possible combinations of a plasmid-encoded gonococcal porin (Por), opacity-associated protein (Opa), and 3F11 lipo-oligosaccharide (LOS) epitope was investigated. Surface expression of Por mediated selective changes in E. coli antibiotic susceptibility, and coexpression of Opa and the 3F11 LOS epitope mediated bacterial clumping (P&lt;.01). In the human fallopian tube organ-culture model, Opa-producing variants attached up to 44-fold better than control bacteria (P&lt;.01), and Por-producing variants exceeded submucosal invasion of control bacteria by 500-fold (P&lt;.01). Opa and Por each facilitated intracellular invasion 20-40-fold (P&lt;.01). In dual expresser variants, the 3F11 LOS epitope markedly reduced attachment and invasion mediated by Opa or Por. The LOS inhibitory effect was curbed when all 3 factors were expressed, which suggests an additional interaction of the 3 factors at the bacterial surface. Por, Opa, and LOS play important roles in Neisseria gonorrhoeae trafficking across human fallopian tube epithelium.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Invasion of Human Fallopian Tube Epithelium by<i>Escherichia coli</i>Expressing Combinations of a Gonococcal Porin, Opacity‐Associated Protein, and Chimeric Lipo‐oligosaccharide

Invasion of Human Fallopian Tube Epithelium byEscherichia coliExpressing Combinations of a Gonococcal Porin, Opacity‐Associated Protein, and Chimeric Lipo‐oligosaccharide