Disseminated Nocardiosis in a Patient with X‐Linked Chronic Granulomatous Disease and Human Immunodeficiency Virus Infection | Zendy

Irini Sereti | Zendy; Steven M. Holland | Zendy

Open Access

Disseminated Nocardiosis in a Patient with X‐Linked Chronic Granulomatous Disease and Human Immunodeficiency Virus Infection

Author(s) -

Irini Sereti,

Steven M. Holland

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/321818

Subject(s) - chronic granulomatous disease , medicine , immunology , nocardiosis , virology , viral disease , immunopathology , human immunodeficiency virus (hiv) , virus , nicotinamide adenine dinucleotide phosphate , nocardia , lentivirus , oxidase test , biology , bacteria , genetics , biochemistry , enzyme

We report the first case of HIV infection in a patient with underlying X-linked chronic granulomatous disease (CGD) who presented with hepatopulmonary nocardiosis. Despite the coexistence of CGD and HIV, the response to therapy was normal, and no unusual sequelae were noted. The patient's high virus burden was successfully repressed with antiretroviral therapy, suggesting that the nicotinamide adenine dinucleotide phosphate oxidase system is not essential for active viral replication or response to antiretroviral agents.

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