Functional Study of Antibodies against a Fibrogenin‐Binding Protein inStaphylococcus epidermidisAdherence to Polyethylene Catheters | Zendy

Lei Pei | Zendy; JanIngmar Flock | Zendy

Open Access

Functional Study of Antibodies against a Fibrogenin‐Binding Protein inStaphylococcus epidermidisAdherence to Polyethylene Catheters

Author(s) -

Lei Pei,

JanIngmar Flock

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/321003

Subject(s) - staphylococcus epidermidis , fibrinogen , microbiology and biotechnology , antibody , in vitro , medicine , staphylococcus aureus , protein a , immunology , chemistry , bacteria , biology , biochemistry , genetics

Staphylococcus epidermidis is an important pathogen in foreign body-associated infections. In a previous study, we showed that a surface-located fibrinogen-binding protein, termed Fbe, from S. epidermidis mediated the bacterial adherence to fibrinogen-coated surfaces in vitro. In the present study, we demonstrate that antibodies against Fbe can block adherence of S. epidermidis to fibrinogen-coated catheters, subcutaneously implanted catheters from rats, and peripheral venous catheters from human patients.

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