Open AccessDiagnosis and Management of Posttransplant Lymphoproliferative Disorder in Solid‐Organ Transplant Recipients
Author(s) -
Jutta K. Preiksaitis,
Susan Keay
Publication year - 2001
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/320903
Subject(s) - medicine , lymphoproliferative disorders , mononucleosis , post transplant lymphoproliferative disorder , solid organ , organ transplantation , immunology , transplantation , epstein–barr virus , epstein–barr virus infection , herpesviridae , pathology , virus , viral disease , lymphoma
The Epstein-Barr virus (EBV) has a pivotal pathophysiologic role in the development of most lymphoproliferative disorders that occur after solid-organ transplantation. The term "EBV-associated posttransplant lymphoproliferative disorder" (PTLD) includes all clinical syndromes of EBV-associated lymphoproliferation, ranging from uncomplicated posttransplant infectious mononucleosis to true malignancies that contain clonal chromosomal abnormalities. PTLDs are historically associated with a high mortality rate in patients who have a monoclonal form of the disorder. Recently described approaches to pathology, diagnosis, treatment, and preventive strategies of PTLD, however, have the potential to improve outcome.