High‐Level Chloroquine Resistance in Sudanese Isolates ofPlasmodium falciparumIs Associated with Mutations in the Chloroquine Resistance Transporter Genepfcrtand the Multidrug Resistance Genepfmdr1 | Zendy

Hamza A. Babiker | Zendy; S. J. Pringle | Zendy; Abdel-Muhsin A. Abdel-Muhsin | Zendy; Margaret J. Mackin | Zendy; Patrick J. Hunt | Zendy; David Walliker | Zendy

Open Access

High‐Level Chloroquine Resistance in Sudanese Isolates ofPlasmodium falciparumIs Associated with Mutations in the Chloroquine Resistance Transporter Genepfcrtand the Multidrug Resistance Genepfmdr1

Author(s) -

Hamza A. Babiker,

S. J. Pringle,

Abdel-Muhsin A. Abdel-Muhsin,

Margaret J. Mackin,

Patrick J. Hunt,

David Walliker

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/320195

Subject(s) - plasmodium falciparum , chloroquine , biology , multiple drug resistance , allele , virology , gene , drug resistance , apicomplexa , genetics , malaria , immunology

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

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