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K76T, a mutation in the Plasmodium falciparum chloroquine (CQ) resistance transporter protein, has been implicated in resistance to CQ. A modified 14-day in vivo test to estimate the CQ resistance level was done in southern Mozambique: 21 (42%) of 50 subjects who completed the follow-up were CQ susceptible. Use of msa2-restriction fragment length polymorphism (RFLP) genotyping to differentiate new from recrudescent infections made little difference in the estimated prevalence of resistance. The K76T mutation prevalence was estimated by RFLP-polymerase chain reaction and sequencing, and its relation to parasitological CQ resistance was explored on day 0 samples: 51 of 56 pretreatment samples presented the T76 codon, and it was present in 100% of children with parasitological resistance. T76 also was present in 18 of 23 subjects in whom the infection resolved after CQ treatment. These findings show a high prevalence of the K76T mutation among wild isolates but also suggest additional factors responsible for CQ resistance.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Prevalence of the K76T Mutation in the Putative<i>Plasmodium falciparum</i>Chloroquine Resistance Transporter<i>(pfcrt)</i>Gene and Its Relation to Chloroquine Resistance in Mozambique

Prevalence of the K76T Mutation in the PutativePlasmodium falciparumChloroquine Resistance Transporter(pfcrt)Gene and Its Relation to Chloroquine Resistance in Mozambique