Discordant HHV8 Detection in a Young HIV-Negative Patient with Kaposi's Sarcoma and Sarcoidosis | Zendy

Gisella Gennaro | Zendy; Vincenzo Canzonieri | Zendy; Ornella Schioppa | Zendy; Guglielmo Nasti | Zendy; Antonino Carbone | Zendy; Umberto Tirelli | Zendy

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Discordant HHV8 Detection in a Young HIV-Negative Patient with Kaposi's Sarcoma and Sarcoidosis

Author(s) -

Gisella Gennaro,

Vincenzo Canzonieri,

Ornella Schioppa,

Guglielmo Nasti,

Antonino Carbone,

Umberto Tirelli

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/319603

Subject(s) - sarcoidosis , medicine , pathogenesis , kaposi's sarcoma , sarcoma , human herpesvirus , immunology , immune system , immunopathology , pathology

Human herpesvirus 8 (HHV8), which has been suggested as the causal agent of Kaposi's sarcoma (KS), has also been implicated in the pathogenesis of sarcoidosis. We describe a patient affected concomitantly by sarcoidosis and KS. HHV8 sequences were detected with PCR only on KS lesions, whereas sarcoid tissues did not harbor HHV8 DNA. Immune dysfunction related to sarcoidosis may have facilitated the oncogenic role of HHV8 and the development of KS.

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