Typhoid Fever and Genetic Polymorphisms at the Natural Resistance–Associated Macrophage Protein 1 | Zendy

Sarah J. Dunstan | Zendy; Vo A. Ho | Zendy; Chau Minh Duc | Zendy; Mai Ngoc Lanh | Zendy; Cao Xuan Thanh Phuong | Zendy; Christine Luxemburger | Zendy; John Wain | Zendy; Frank Dudbridge | Zendy; Christopher S. Peacock | Zendy; Deborah House | Zendy; Christopher Parry | Zendy; Tran Tinh Hien | Zendy; Gordon Dougan | Zendy; Jeremy Farrar | Zendy; Jenefer M. Blackwell | Zendy

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Typhoid Fever and Genetic Polymorphisms at the Natural Resistance–Associated Macrophage Protein 1

Author(s) -

Sarah J. Dunstan,

Vo A. Ho,

Chau Minh Duc,

Mai Ngoc Lanh,

Cao Xuan Thanh Phuong,

Christine Luxemburger,

John Wain,

Frank Dudbridge,

Christopher S. Peacock,

Deborah House,

Christopher Parry,

Tran Tinh Hien,

Gordon Dougan,

Jeremy Farrar,

Jenefer M. Blackwell

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/319289

Subject(s) - typhoid fever , allele , genotype , biology , salmonella enterica , genetics , immunology , virology , salmonella , gene , bacteria

Control of Salmonella enterica serovar Typhimurium (S. typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural resistance-associated macrophage protein 1 (Nramp1). In this study, we examined the role of genetic polymorphisms in the human homologue, NRAMP1, in resistance to typhoid fever in southern Vietnam. Patients with blood-culture-confirmed typhoid fever and healthy control subjects were genotyped for 6 polymorphic markers within and near NRAMP1 on chromosome 2q35. Four single base-pair polymorphisms (274 C/T, 469+14 G/C, 1465-85 G/A, and D543N), a (GT)(n) repeat in the promoter region of NRAMP1 and D2S1471, and a microsatellite marker approximately 130-kb downstream of NRAMP1 were examined. The allelic and genotypic frequencies for each polymorphism were compared in case patients and control subjects. No allelic association was identified between the NRAMP1 alleles and typhoid fever susceptibility. In addition, neither homozygotes nor heterozygotes for any NRAMP1 variants were at increased risk of typhoid fever.

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