Recurrences of Cytomegalovirus Retinitis in a Human Immunodeficiency Virus-Infected Patient, Despite Potent Antiretroviral Therapy and Apparent Immune Reconstitution | Zendy

Steven C. Johnson | Zendy; Constance A. Benson | Zendy; David W. Johnson | Zendy; Adriana Weinberg | Zendy

Open Access

Recurrences of Cytomegalovirus Retinitis in a Human Immunodeficiency Virus-Infected Patient, Despite Potent Antiretroviral Therapy and Apparent Immune Reconstitution

Author(s) -

Steven C. Johnson,

Constance A. Benson,

David W. Johnson,

Adriana Weinberg

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/319219

Subject(s) - medicine , retinitis , cytomegalovirus retinitis , antiretroviral therapy , virology , cytomegalovirus , human immunodeficiency virus (hiv) , aids related opportunistic infections , immune system , human cytomegalovirus , immunology , sida , immunopathology , immune reconstitution inflammatory syndrome , viral disease , virus , herpesviridae , viral load

We describe a 42-year-old man with human immunodeficiency virus infection who developed multiple recurrences of cytomegalovirus (CMV) retinitis despite receiving highly active antiretroviral therapy and having apparent immune reconstitution as evidenced by CD4(+) T lymphocyte counts of > 200 cells/mm(3). Laboratory investigation during one recurrence of retinitis confirmed that there was active CMV replication in the plasma and vitreous fluid. In addition, lymphoproliferative responses to CMV antigens were absent despite evidence of reactivity to Candida antigen and pokeweed mitogen. The clinical significance of this case and of other recently reported cases is discussed.

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