Open AccessAzithromycin and Gentamicin Therapy for the Treatment of Humans with Brucellosis
Author(s) -
Javier Solera,
José Luís Beato,
Elisa Martı́nez-Alfaro,
Juan Carlos Segura,
Elena Tomàs
Publication year - 2001
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/318503
Subject(s) - azithromycin , medicine , brucellosis , gentamicin , confidence interval , antibacterial agent , antibiotics , surgery , immunology , microbiology and biotechnology , biology
Ten patients with brucellosis were treated with azithromycin and gentamicin to assess the treatment's safety and efficacy. Seven patients had an excellent therapeutic response at the end of therapy; however, relapse was noted in 3. When relapse was considered in combination with an initial lack of efficacy, 5 patients (50%; 95% confidence interval, 18.7%-81.3%) did not respond to therapy; these results do not favor the use of azithromycin to treat brucellosis in humans.