Open AccessThe HLA A2/6802 Supertype Is Associated with Reduced Risk of Perinatal Human Immunodeficiency Virus Type 1 Transmission
Author(s) -
Kelly S. MacDonald,
Joanne E. Embree,
Nico J. D. Nagelkerke,
José Brea del Castillo,
Susie Ramhadin,
Simon Njenga,
Julius Oyug,
J.O. NdinyaAchola,
Brian H. Barber,
Job J. Bwayo,
Francis A. Plummer
Publication year - 2001
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/318092
Subject(s) - human leukocyte antigen , odds ratio , immunology , virology , epitope , transmission (telecommunications) , allele , cohort , biology , medicine , antibody , antigen , genetics , gene , electrical engineering , engineering
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P=.006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.
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