Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain | Zendy

Michiel van der Flier | Zendy; Guenther Stockhammer | Zendy; Gemma J. H. Vonk | Zendy; Peter G. J. Nikkels | Zendy; Ronnie A. A. M. van Diemen–Steenvoorde | Zendy; G. J. van der Vlist | Zendy; Stijn W. M. Rupert | Zendy; Erich Schmutzhard | Zendy; Eberhard Gunsilius | Zendy; Guenther Gastl | Zendy; Andy I. M. Hoepelman | Zendy; Jan L. L. Kimpen | Zendy; Sibyl P. M. Geelen | Zendy

Open Access

Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain

Author(s) -

Michiel van der Flier,

Guenther Stockhammer,

Gemma J. H. Vonk,

Peter G. J. Nikkels,

Ronnie A. A. M. van Diemen–Steenvoorde,

G. J. van der Vlist,

Stijn W. M. Rupert,

Erich Schmutzhard,

Eberhard Gunsilius,

Guenther Gastl,

Andy I. M. Hoepelman,

Jan L. L. Kimpen,

Sibyl P. M. Geelen

Publication year - 2001

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/317643

Subject(s) - meningitis , cerebrospinal fluid , vascular endothelial growth factor , medicine , pathology , viral meningitis , csf albumin , vascular permeability , blood–brain barrier , cerebral edema , immunology , bacterial meningitis , vegf receptors , central nervous system , surgery

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of VEGF during bacterial meningitis, VEGF was measured in cerebrospinal fluid (CSF) and blood of 37 patients with bacterial meningitis and 51 control patients, including 16 patients with viral meningitis. Circulating VEGF levels were similar in bacterial meningitis patients and control patients. VEGF(CSF) was detected in 11 (30%) of 37 of bacterial meningitis patients (range, <25-633 pg/mL) but in none of the control patients. The median VEGF index was 6.2 (range, 0.6-42), indicating intrathecal production. Median CSF cell counts, protein levels, and CSF: serum albumin ratios were higher for patients with detectable VEGF(CSF), although the difference was not statistically significant. VEGF immunoreactivity in autopsy brain specimens was found in the inflammatory infiltrate of patients with bacterial meningitis. These results indicate that inflammatory cells secrete VEGF during bacterial meningitis and that VEGF may contribute to blood-brain barrier disruption.

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