Reactivation and Shedding of Cytomegalovirus in Astronauts during Spaceflight | Zendy

Satish Mehta | Zendy; Raymond P. Stowe | Zendy; Alan H. Feiveson | Zendy; Stephen K. Tyring | Zendy; Duane L. Pierson | Zendy

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Reactivation and Shedding of Cytomegalovirus in Astronauts during Spaceflight

Author(s) -

Satish Mehta,

Raymond P. Stowe,

Alan H. Feiveson,

Stephen K. Tyring,

Duane L. Pierson

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/317624

Subject(s) - spaceflight , titer , cytomegalovirus , urine , immunology , viral shedding , medicine , antibody , virology , biology , virus , herpesviridae , viral disease , engineering , aerospace engineering

The reactivation of cytomegalovirus (CMV) in 71 astronauts was investigated, using polymerase chain reaction. A significantly greater (P<.0001) shedding frequency was found in urine samples from astronauts before spaceflight (10.6%) than in urine from the healthy control subject group (1.2%). Two of 4 astronauts studied during spaceflight shed CMV in urine. A significant increase (P<.0001) in CMV antibody titer, compared with baseline values, was also found 10 days before spaceflight. CMV antibody titer was further increased (P<.001) 3 days after landing, compared with 10 days before the mission. Significant increases in stress hormones were also found after landing. These results demonstrate that CMV reactivation occurred in astronauts before spaceflight and indicate that CMV may further reactivate during spaceflight.

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