The GB Virus C/Hepatitis G Virus Replicates in Hepatocytes without Causing Liver Disease in Healthy Blood Donors | Zendy

Robert Halasz | Zendy; Matti Sällberg | Zendy; Suzana Lundholm | Zendy; Göran Andersson | Zendy; Björn Lager | Zendy; Hans Glaumann | Zendy; Ola Weiland | Zendy

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The GB Virus C/Hepatitis G Virus Replicates in Hepatocytes without Causing Liver Disease in Healthy Blood Donors

Author(s) -

Robert Halasz,

Matti Sällberg,

Suzana Lundholm,

Göran Andersson,

Björn Lager,

Hans Glaumann,

Ola Weiland

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/317610

Subject(s) - gb virus c , virus , virology , liver biopsy , liver disease , hepatitis c virus , flaviviridae , medicine , hepatitis , chronic liver disease , polymerase chain reaction , pathology , biology , immunology , biopsy , cirrhosis , gene , biochemistry

Thirty-seven persons were identified with GB virus C (GBV-C) single infection by polymerase chain reaction screening of 1254 healthy blood donors. Of 33 donors who returned for clinical examination, 17 underwent liver biopsy. Clinical, biochemical, and histologic evaluation did not reveal any signs of liver disease. Liver biopsies of 15 donors were analyzed by in situ hybridization with GBV-C RNA probes and immunologic staining for the GBV-C envelope 2 protein. GBV-C replication was identified in the cytoplasm of hepatocytes of 10 (67%) donor livers but in none of 7 liver biopsies of chronic hepatitis B virus carriers negative for serum GBV-C RNA. Thus, there was no evidence of liver disease in GBV-C-infected healthy blood donors despite viral replication in hepatocytes.

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