Choosing a Route of Administration for Quadrivalent Meningococcal Polysaccharide Vaccine: Intramuscular versus Subcutaneous | Zendy

Frederick L. Ruben | Zendy; James E. Froeschle | Zendy; Carlton Meschievitz | Zendy; K. Chen | Zendy; James N. George | Zendy; Mary-Kate Reeves-Hoché | Zendy; Patricia J. Freda Pietrobon | Zendy; Mike Bybel | Zendy; William C. Livingood | Zendy; Lynn D. Woodhouse | Zendy

Open Access

Choosing a Route of Administration for Quadrivalent Meningococcal Polysaccharide Vaccine: Intramuscular versus Subcutaneous

Author(s) -

Frederick L. Ruben,

James E. Froeschle,

Carlton Meschievitz,

K. Chen,

James N. George,

Mary-Kate Reeves-Hoché,

Patricia J. Freda Pietrobon,

Mike Bybel,

William C. Livingood,

Lynn D. Woodhouse

Publication year - 2001

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/317553

Subject(s) - medicine , intramuscular injection , erythema , titer , meningococcal disease , neisseria meningitidis , route of administration , antibody titer , immunology , antibody , pharmacology , anesthesia , bacteria , biology , genetics

A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P<.01) and reduced headache on days 1 and 2 (P<.05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.

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