Acute Renal Failure: Unusual Complication of Epstein‐Barr Virus–Induced Infectious Mononucleosis | Zendy

Paul Lei | Zendy; Amy Lowichik | Zendy; Wain Allen | Zendy; Teri Jo Mauch | Zendy

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Acute Renal Failure: Unusual Complication of Epstein‐Barr Virus–Induced Infectious Mononucleosis

Author(s) -

Paul Lei,

Amy Lowichik,

Wain Allen,

Teri Jo Mauch

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/317497

Subject(s) - medicine , mononucleosis , epstein–barr virus , cytotoxic t cell , interstitial nephritis , virus , immunology , renal biopsy , epstein–barr virus infection , complication , pathology , virology , kidney , biopsy , biochemistry , chemistry , in vitro

A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.

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