Tissue Distribution and Variant Characterization of Human Herpesvirus (HHV)–6: Increased Prevalence of HHV‐6A in Patients with Multiple Sclerosis | Zendy

Nahid Akhyani | Zendy; Rossana Berti | Zendy; Meghan B. Brennan | Zendy; Samantha S. Soldan | Zendy; Joan M. Eaton | Zendy; Henry F. McFarland | Zendy; Steven Jacobson | Zendy

Open Access

Tissue Distribution and Variant Characterization of Human Herpesvirus (HHV)–6: Increased Prevalence of HHV‐6A in Patients with Multiple Sclerosis

Author(s) -

Nahid Akhyani,

Rossana Berti,

Meghan B. Brennan,

Samantha S. Soldan,

Joan M. Eaton,

Henry F. McFarland,

Steven Jacobson

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315893

Subject(s) - human herpesvirus 6 , multiple sclerosis , pathogenesis , saliva , herpesviridae , virology , serology , immunology , peripheral blood mononuclear cell , pathology , urine , medicine , viral disease , biology , virus , antibody , in vitro , biochemistry

Human herpesvirus (HHV)-6 has been associated with the pathogenesis of multiple sclerosis (MS) on the basis of serologic, molecular, and histopathologic studies. This study sought to determine the distribution of HHV-6 in different MS body fluids, including serum, saliva, urine, and peripheral blood lymphocytes. The study results extend the observation of an increased frequency of HHV-6 DNA in serum of patients with MS to the unique detection of viral sequences in urine of a subset of patients with MS. Moreover, the HHV-6 identified in these cell-free compartments was predominantly the HHV-6A variant, which has been reported to be neurotropic. These results support the hypothesis that HHV-6 may contribute to the MS disease process.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research